About the author
Dr. Anastacia Munro, MD, is the Medical Director of Parie Med Spa and a fellowship-trained anesthesiologist with more than 10 years of experience in patient care and procedural medicine. She oversees Parie’s clinical standards with a focus on patient safety and evidence-based care.
Professional profiles: Doximity · Healthgrades · Summerlin Hospital directory · NPI Registry
TLDR: NAD+ IVs have not been shown to help you lose weight. Keep food, activity, sleep and stress management at the center of your plan.
Human evidence does not show that NAD+ IVs cause weight loss, and findings from oral supplements do not demonstrate an IV benefit.
You want the plain truth: does NAD+ help with weight loss? Our team reviewed 13 primary sources for this guide, from NIH, CDC and FDA to published studies. NAD+ has a role in your body’s energy production, but adding it through an IV has no demonstrated weight benefit.
Does NAD+ help with weight loss in human studies?
You should not expect weight loss from an NAD+ IV. A 2026 meta-analysis of oral NMN trials found no significant body weight or BMI effect, a finding about oral NAD+ precursors rather than IV NAD+. The 2026 retrospective commercial IV records review, with six NAD+ clients, no placebo and authors employed by the IV company, found no significant body-composition change. The human evidence does not support using an infusion to change your weight.
For your daily routine, the CDC’s guidance on healthy weight loss centers on healthy eating patterns, regular physical activity, enough sleep and stress management. That means food, movement and rest stay central when you consider an IV. Personal medical care fits alongside those habits when you need individual guidance. Cleveland Clinic’s expert guidance says IV vitamin therapy does not replace a healthy diet or undo habits involving nutrition, exercise, sleep and stress management.
For a claim about NAD+ for weight loss, look for a measured change in weight or body composition in people. A blood reading alone does not tell you that someone lost weight. An oral supplement trial also does not tell you what an IV will do. The substance, the route and the measured result all need to match the claim.
What does NAD+ do in your metabolism?
NAD+ takes part in the reactions that turn energy from your food into a form your cells use. According to the NIH fact sheet on niacin, those reactions transfer energy from carbohydrates, fats and proteins to ATP, your cells’ main energy currency. This is normal energy metabolism. It explains why NAD+ attracts interest, without making an infusion a weight-loss tool.
Niacin, also called vitamin B3, helps turn the food you eat into energy, as NIH explains in its consumer fact sheet. The background biology in Grant’s 2019 pilot describes NAD+ and NADH as central to energy production in mitochondria, rather than reporting an infusion benefit. These are descriptions of what happens within your body. Neither statement tells you that receiving extra NAD+ through a vein changes your weight.
A molecule’s everyday role is only the beginning of the science you need for a claim about an infusion. For your reading, distinguish a study of an oral product from a report about an IV. Then identify the outcome being measured, such as body composition or a blood level. Those measurements answer different questions, even when NAD+ appears in the study description.
Does NAD+ help with weight loss when studied as oral precursors?
Oral precursor studies give you little reason to expect a weight benefit. In Dollerup’s 2018 oral nicotinamide riboside trial, 40 healthy, sedentary men with a BMI above 30 received oral NR or placebo for 12 weeks, with no effect on body composition. You still need data about the IV route before drawing a conclusion about an infusion. The result concerns that supplement and study population, not an NAD+ IV.
If you are reading about NMN weight loss, the 2026 meta-analysis of oral NMN trials found no significant effect on body weight or BMI and no broad metabolic benefits, without testing IV NAD+. For your decision, the distinction between swallowing a supplement and receiving an IV matters. It offers no weight-loss finding to carry over to an IV.
One small trial complicates a claim that nothing ever changed. Remie’s small 2020 oral NR crossover trial reported minor changes in body composition and energy use during sleep, with no other metabolic health effects observed. You should keep those modest findings in view alongside the null results. They still concern oral NR, with no weight-loss result from an NAD+ infusion.
| What was studied? | What does the result tell you? |
|---|---|
| Body composition | The 2018 randomized oral NR trial in 40 healthy, sedentary men with a BMI above 30 found no body-composition effect after 12 weeks versus placebo, without testing IV NAD+. |
| Body weight and BMI | The 2026 meta-analysis of oral NMN trials found no significant body weight or BMI effect, without testing IV NAD+. |
| Body composition and sleep | The small 2020 oral NR crossover trial found minor body-composition and sleeping energy-use changes, with no other metabolic health effects observed. |
What have IV NAD+ studies measured?
IV studies have measured blood and urine levels, tolerability and body composition, without showing a weight benefit for you. Grant’s 2019 pilot in 11 healthy men tracked blood and urine levels during a slow six-hour IV infusion, measured no wellness outcome and had authors with NAD+ clinic ties. For you, that means the measurements do not answer a question about weight loss. The study’s small size and clinic ties also deserve attention.
A 2026 retrospective commercial IV records review of six NAD+ IV clients and eight NR IV clients found no significant body-composition changes at 30 days or between groups, with no placebo and authors employed by the IV company. That design gives you no placebo comparison for interpreting the result. For you, this is a small retrospective report, not a reliable forecast of a result from booking an infusion.
Broader reviews also leave you without a demonstrated IV weight benefit. A 2026 systematic review, searching through October 2025, found no eligible outcome trials of IV or intramuscular NAD+ itself for wellness. A September 2026 narrative review described IV findings as preliminary and insufficient for routine wellness use. The earlier search ended before the 2026 records review, so these reports cover different periods and types of work.
For more detail, your companion guide to what NAD+ IV studies show so far follows the IV findings. Blood levels, symptoms during an infusion and body composition each tell you something different. None of the IV results here supplies a demonstrated weight-loss benefit. A higher measurement in blood is not a lower number on your scale.
What should you know about NAD+ IV side effects?
NAD+ IVs have reported side effects that you should take seriously. In the 2026 retrospective commercial IV records review, six NAD+ IV clients reported moderate to severe digestive symptoms, increased heart rate and chest pressure during infusions, with no placebo and authors employed by the IV company. These are observations from a limited report. They do not tell you how often these symptoms occur across everyone receiving NAD+ IVs.
Ingredient quality also matters when you consider injectable NAD+. In its 2024 reminder about sterile compounding ingredients, the FDA described reports of severe chills, shaking, vomiting and tiredness after injectable NAD+. The FDA’s October 30, 2024 ingredient-quality reminder said the reactions reported after injectable NAD+ were consistent with excessive endotoxin levels, without giving a rate. Ask where the ingredients come from, without assuming that these reports describe any particular lounge’s sourcing.
Your health history matters before any IV vitamin visit. Cleveland Clinic advises avoiding IV vitamin therapy if you are seeing a healthcare professional for heart disease, high blood pressure, kidney disease or pregnancy. Cleveland Clinic’s expert guidance also says direct general wellness benefits from IV vitamin therapy in healthy people have limited scientific support. This is general IV vitamin guidance, not an NAD+ weight trial.
- Tell your provider about your heart and kidney health, blood pressure and any pregnancy.
- Share every medicine you take before choosing an IV.
- Ask where the NAD+ ingredients come from.
- Keep meals, physical activity, sleep and stress management in your weight-loss plan.
What does The Drip Room offer you in Summerlin?
The Drip Room is an IV lounge at 1725 Village Center Cir #110 in Summerlin, Las Vegas, and a sister brand of Parie Med Spa. Its ten signature drips are formulated by medical professionals and delivered by licensed providers. Your options also include NAD+ IVs and booster shots.
When planning your visit, The Drip Room is open Monday to Sunday, 9 AM to 7 PM. The lounge’s phone number is (725) 248-1113. You will find its NAD+ IV doses, add-on and shot listed below.
NAD+ and Weight Loss FAQ
Does NAD+ change your metabolism?
No increase in resting energy expenditure, the energy you use at rest, was found in the 2018 randomized oral NR trial in 40 healthy, sedentary men with a BMI above 30 compared with placebo over 12 weeks. That result concerns an oral NAD+ precursor, not an NAD+ IV.
Is an NAD+ IV better than NAD+ supplements for weight loss?
No evidence here shows that an IV is better for your weight. Martens’ small 2018 crossover trial of oral NR in healthy middle-aged and older adults reported higher NAD+ levels, a result about blood biomarkers rather than a demonstrated wellness outcome. A blood-level change does not settle the choice between supplements and an IV.
What does an NAD+ IV feel like?
The studies do not predict what you will feel. Grant’s 2019 pilot in 11 healthy men reported no adverse events during a slow six-hour IV infusion in either the NAD+ or saline group, but measured only blood and urine levels, no wellness outcome, and had authors with NAD+ clinic ties. That small observation does not promise the same experience for you.
What are the side effects of NAD+ IV therapy?
Reported symptoms in the 2026 retrospective commercial IV records review of six NAD+ IV clients included digestive symptoms, increased heart rate and chest pressure, with no placebo and authors employed by the IV company. Beyond those NAD+ findings, Cleveland Clinic’s IV guidance lists bruising at the needle site and negative interactions with medicines among possible IV vitamin therapy risks. It gives no rates, so the list does not tell you how common those risks are.
Can NAD+ replace diet and exercise?
No. Cleveland Clinic says IV vitamin therapy is not a substitute for a healthy diet or prescribed medicines. It also does not undo habits involving nutrition, exercise, sleep and stress, so your routine and medical care remain central.
What NAD+ options does The Drip Room offer?
The Drip Room offers NAD+ IVs in 250 mg, 500 mg and 1,000 mg doses, a 100 mg NAD+ add-on to any drip and a 100 mg NAD+ shot among its listed booster shots. Those are available formats, without a demonstrated weight-loss advantage for you.
Want to learn about your NAD+ IV options? Read the NAD+ IV page for The Drip Room in Summerlin, Las Vegas. Book your drip at the lounge.
Like this article? Add The Drip Room as a preferred source, and you are more likely to see our articles in Google’s Top Stories.
