About the author
Dr. Anastacia Munro, MD, is the Medical Director of Parie Med Spa and a fellowship-trained anesthesiologist with more than 10 years of experience in patient care and procedural medicine. She oversees Parie’s clinical standards with a focus on patient safety and evidence-based care.
Professional profiles: Doximity · Healthgrades · Summerlin Hospital directory · NPI Registry
TLDR: A 2026 narrative review found NAD+ IV evidence preliminary and insufficient for routine wellness use. Before you book, check the reported risks and the difference between a drip and a pill.
NAD+ helps your cells produce energy, but a 2026 narrative review found the evidence for NAD+ IV therapy preliminary and insufficient to support routine wellness use.
You want NAD+ IV therapy benefits that mean something beyond a blood test. Here’s the plain truth: a normal nutrient function is no promise of a drip benefit. Our team reviewed 12 primary sources for this guide, from NIH, FDA and Cleveland Clinic to published studies.
A molecule’s job inside your cells is one thing. An added dose through a needle is another. Cleveland Clinic’s 2026 expert guidance on IV vitamin services for general wellness in healthy people describes limited scientific backing for direct benefits and a need for high-quality studies. For you, that guidance supplies context, rather than a trial of NAD+ itself.
What is NAD+ IV therapy, and what does NAD+ do in your body?
NAD+ IV therapy delivers NAD+ through an intravenous infusion, while your cells already use this molecule in everyday reactions. According to the NIH niacin fact sheet, more than 400 enzymes require NAD+ made from niacin to carry out reactions in the body. In its normal role, NAD+ helps transfer energy from carbohydrates, fats and proteins to ATP, the cell’s main energy currency. That is normal energy metabolism.
Vitamin B3 connects this chemistry to the food you eat. The NIH consumer guide explains that niacin, also called vitamin B3, normally helps turn food into energy. These are nutrient functions. They offer no promise about how an IV will make you feel.
Inside your cells, NAD+ and NADH are central to energy production in mitochondria, as the 2019 IV pilot’s biochemical background explains. These biochemical pathways describe normal functions. Your question about an infusion needs a separate answer: what did the study measure?
What do human studies show about NAD+ IV therapy benefits?
Human IV findings need context before you use them to plan a visit. A 2019 pilot study of 11 healthy men aged 30 to 55, eight receiving NAD+ IV and three saline during slow six-hour infusions, tracked blood and urine levels without a wellness outcome, and its authors had NAD+ clinic ties. Read a blood measurement as a blood measurement. It does not tell you how your day will feel.
No adverse events were observed during slow six-hour NAD+ or saline IV infusions in the 2019 pilot of 11 healthy men aged 30 to 55, which measured blood and urine rather than wellness outcomes and had authors with NAD+ clinic ties. For you, that is a limited observation. It is no promise about every infusion.
More recent IV records give you another reason to review symptoms before booking. A 2026 retrospective review of commercial IV records, with six NAD+ IV clients, eight NR IV clients, no placebo and authors employed by the commercial IV provider, recorded moderate to severe digestive symptoms, increased heart rate and chest pressure in the NAD+ group. NR means nicotinamide riboside. Keep that substance separate from NAD+ when you compare findings.
Two reviews put those findings in context for you. A 2026 systematic review, searching through October 2025, found no eligible wellness outcomes trials of IV or intramuscular NAD+ itself, with its search ending before the 2026 commercial records report. A September 2026 narrative review described IV NAD+ evidence as preliminary and insufficient to support routine clinical or wellness use.
Do NR and NMN pills show NAD+ IV therapy benefits?
Oral supplement findings do not tell you what an NAD+ IV will do. A small 2018 oral NR crossover trial in healthy middle-aged and older adults reported changes in NAD+ metabolism and well-tolerated supplementation, a blood-marker finding rather than a wellness outcome. Your comparison needs to keep both route and outcome in view.
For oral NMN, a 2026 meta-analysis of oral NMN trials found no evidence of broad metabolic benefits and no significant effects on body weight, BMI or systolic blood pressure, without testing IV NAD+. These results concern nutritional supplements taken by mouth. They give you no basis for ranking an NAD+ IV above a pill.
At a glance, the table lets you compare findings with their limits. Each row identifies the route. Read the finding and its limit together before applying it to your plans.
| Study and route | Finding and limit for you |
|---|---|
| 2019 NAD+ IV pilot | The 2019 pilot tracked blood and urine during slow six-hour NAD+ or saline IV infusions in 11 healthy men aged 30 to 55, with no wellness outcome and authors with NAD+ clinic ties. |
| 2026 NAD+ IV and NR IV records | The 2026 retrospective commercial records review, with six NAD+ IV clients, eight NR IV clients, no placebo and authors employed by the IV business, recorded moderate to severe digestive symptoms, increased heart rate and chest pressure in NAD+ recipients. |
| 2018 oral NR crossover trial | The small 2018 oral NR crossover trial in healthy middle-aged and older adults reported changed NAD+ metabolism and well-tolerated supplementation, a blood-marker result rather than a wellness outcome. |
| 2026 oral NMN meta-analysis | The 2026 meta-analysis of oral NMN trials found no significant effects on body weight, BMI or systolic blood pressure, without testing IV NAD+. |
In the 2026 retrospective commercial records review of six NAD+ IV and eight NR IV clients, no significant body-composition changes appeared from baseline to 30 days or between groups, with no placebo and authors employed by the IV business. For you, that comparison does not answer a question about pills. It also does not show a weight change to expect from a drip.
What should you know about NAD+ IV therapy side effects?
Reported symptoms deserve your attention before booking. The FDA’s October 2024 ingredient-quality reminder described reports of severe chills, shaking, vomiting and fatigue after NAD+ injectable products, without giving a reaction rate. That ingredient-quality notice does not tell you anything about The Drip Room’s own sourcing.
Ingredient sourcing is worth checking before your visit. Ask where the NAD+ ingredients come from. Avoid assuming that every symptom in every report has the same cause.
Your health history also matters before an IV. Cleveland Clinic’s general IV vitamin safety guidance advises avoiding IV vitamin services if you are seeing a healthcare professional for heart disease, high blood pressure, kidney disease or pregnancy. These are reasons to speak with the professional who knows your health history before booking.
- Tell your provider about your heart and kidney health, pregnancy and every medicine you take.
- Ask where the NAD+ ingredients come from.
- Request an explanation of the reported infusion symptoms before you book.
Which NAD+ IV options does The Drip Room offer?
The Drip Room offers you NAD+ IVs in 250 mg, 500 mg and 1,000 mg doses. Its offerings also include a 100 mg NAD+ add-on to any drip and a 100 mg NAD+ booster shot. You will find the formats on the NAD+ IV options page and the booster shot page.
A larger listed amount does not give you evidence of a stronger result. Study schedules do not tell you the length of a lounge appointment. For more on another nutrient, read the companion guide to B12 and IV therapy.
What does The Drip Room offer you in Summerlin?
The Drip Room is an IV lounge at 1725 Village Center Cir #110 in Summerlin, Las Vegas, and a sister brand of Parie Med Spa. Its ten signature drips are formulated by medical professionals and delivered by licensed providers. Your options also include NAD+ IVs and booster shots.
For your visit, The Drip Room is open Monday to Sunday from 9 AM to 7 PM. Its phone number is (725) 248-1113. Review the NAD+ IV page before booking.
NAD+ IV Therapy FAQ
What is NAD+ IV therapy?
It is NAD+ delivered to you through an intravenous infusion. The 2019 pilot abstract reported rapid, complete plasma removal for at least the first two hours at the studied NAD+ IV rate in a pilot of 11 healthy men aged 30 to 55 with slow six-hour infusions, blood-and-urine measurements without wellness outcomes and authors with NAD+ clinic ties. That blood finding does not show a benefit you would notice.
What are the benefits of NAD+ IV therapy, according to research?
According to the 2026 narrative review, IV NAD+ evidence is insufficient for routine wellness use. For you, related pill findings also need limits: a 2018 randomized placebo-controlled trial of oral NR, 1,000 mg twice daily for 12 weeks, in 40 healthy, sedentary men aged 40 to 70 with BMI above 30 found no effect on resting energy expenditure or body composition, without testing IV NAD+.
What does an NAD+ IV feel like?
Moderate to severe digestive symptoms, increased heart rate and chest pressure were reported by NAD+ recipients in the 2026 retrospective commercial records review of six NAD+ IV and eight NR IV clients receiving 500 mg of their assigned substance on four consecutive days with 30-day follow-up, no placebo and authors employed by the IV business. Those records do not predict your experience or describe a visit at The Drip Room.
What are the side effects of NAD+ IV therapy?
The FDA’s October 2024 ingredient-quality reminder lists reports of severe chills, shaking, vomiting and fatigue following NAD+ injectable products, without a reaction rate. Beyond that NAD+ notice, Cleveland Clinic’s general IV vitamin guidance lists possible bruising at the needle site and negative interactions with medicines you take, without giving rates.
Is an NAD+ IV better than NR or NMN pills?
No IV advantage over pills is shown for you in these findings. The 2026 meta-analysis of oral NMN trials found no significant effects on fasting glucose, HbA1c or lipid profiles, without testing IV NAD+. Keep those oral measurements separate from a claim about an infusion.
What NAD+ doses does The Drip Room offer?
You have 250 mg, 500 mg and 1,000 mg NAD+ IV options, a 100 mg NAD+ add-on to any drip and a 100 mg NAD+ booster shot. For comparison, the 2019 pilot of 11 healthy men aged 30 to 55 used 750 mg NAD+ in normal saline over slow six-hour IV infusions, measuring blood and urine without a wellness outcome, with authors who had NAD+ clinic ties. A study dose is no recommendation for you.
Want to review your NAD+ IV options? Read about NAD+ IVs at The Drip Room in Summerlin, Las Vegas. Book your drip through the contact page.
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